Exact(7)
Autophagy-deficient Atg5−/− MEFs and lysosomal acidification impaired cells surrender to infection.
When the error-prone pathway is impaired, cells become refractory to spontaneous and damage-induced mutagenesis; when the error-free pathway is impaired, cells become, if anything, more susceptible to damage-induced mutagenesis.
Our data suggest that cancer cells require active SCD1 to control the rate of glucose-mediated lipogenesis, and that when SCD1 activity is impaired cells downregulate SFA synthesis via AMPK-mediated inactivation of acetyl-CoA carboxylase, thus preventing the harmful effects of SFA accumulation.
When OXPHOS is impaired, cells need to develop strategies to compensate for the metabolic defect.
Inflammatory response not only eliminates impaired cells and invading pathogens, but it also actively promotes wound healing.
In thermally injured mice, GA regulates the burn-associated type 2 T cell responses to recover IL-12 and make it unresponsive, thus restoring the impaired cells [ 74].
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For instance, genetic deletion of Perk or impairment of eIF2α activity impaired cell survival [9], [10].
For all stressors, the SG-promoting compound C85 impaired cell survival and induce cell death.
Accordingly, knockdown of Dicer impaired cell growth by reducing growth-correlating microRNA transcripts.
Cryptococcus neoformans is an opportunistic fungal pathogen that threatens individuals with impaired cell-mediated immunity (CMI).
Exposing hMVEC to 50 and 95% O2 for more than 24 h impaired cell viability and proliferation.
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