Suggestions(1)
Exact(3)
Patients with septic shock have impaired baroreceptor function, and this is correlated with progression to death.
The lack of increase in venous NA during ATP infusion in the group with diabetes may be to the result of an impaired baroreceptor function (25) or altered function of the ATP inducement of NA exocytosis because the changes in MAP during ATP infusions were similar in the two groups.
GH substitution resulted in an impaired baroreceptor function.
Similar(57)
Targeted disruption of this gene causes hypertension, tachycardia and impaired baroreceptor reflexes in mice [35], [36]; and its overexpression in pancreatic islets contributes to type 2 diabetes [37].
As such a wide variety of activities may be prescribed to ameliorate arterial stiffness and potentially improve baroreceptor function in some populations.
Baroreceptor function and rheological properties of the aortic wall are considered to develop with morphological growth of the heart, blood vessels, and other cardiovascular components.
Waki et al. [ 10] investigated changes in the MAP level and baroreceptor function with postnatal development in SD rats at 3, 8, and 20 weeks of age and reported that MAP level reached mature level by 8 weeks, although the sensitivity of baroreceptors was significantly smaller at 3 and 8 weeks than at 20 weeks.
The gender difference is consistent with other studies, and may be related to differences in baroreceptor function; thus, we defined gender-specific cut-off values for resting HR (Table 3) [ 19, 27].
To this end, the effect of central administration of CGP42112, a selective AT2 receptor agonist, or PD123319, a selective AT2 receptor antagonist on high-pressure baroreceptor function, was compared in the presence or absence of the NOS inhibitor L-NAME.
Dobutamine is known to increase HR and BP artificially and also to blunt baroreceptor function (van de Borne et al. 1999; Zaza and Lombardi 2001), which normally would elicit a vagal reflex when BP increases.
Both GH and Hx rats showed reduced vasculature mass in the hindquarter vascular bed, but only GH treated rats exhibit impaired function of the baroreceptors, suggesting that the blunted function of the baroreceptors could not be due to loss of structure in the baroreceptors in GH rats.
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