Sentence examples for impaired availability from inspiring English sources

Mechanisms of adrenal dysfunction, particularly in the course of sepsis and shock, may include impaired availability or cleaving of the substrate (HDL- cholesterol and impaired activity of steroidogenic enzymes, limiting an adequate adrenal stress (ACTHDL- cholesterol 6, 12- 15] (see Figure 1).

Some studies have suggested the possibility of impaired availability of tryptophan and disturbances in central serotonergic function as playing a role [ 9, 12].

NO insufficiency e.g., in atherosclerosis, hypertension, arterial thrombotic disorders, heart failure, coronary heart disease, and stroke [ 11, 17, 127– 134]—may reflect an absolute deficit of NO (synthesis), impaired availability of bioactive NO, or enhanced NO inactivation.

This finding pointing towards impaired availability of adhesion molecules contributing to the ASML-exosome-mediated blockade in T cell migration, we controlled, which antibodies interfere with migration in the absence of exosomes.

They could also be associated with dopaminergic dysfunction due to impaired availability of tyrosine, since dopamine is known to exert an inhibitory action on prolactin release in the hypothalamus [ 26].

Although our results of the amino acid analysis and prolactin levels in adolescents are only preliminary, they give support to previous findings on patients with coeliac disease, suggesting that serotonergic dysfunction due to impaired availability of tryptophan may play a role in vulnerability to depressive and behavioural disorders also among adolescents with untreated coeliac disease.

It is thus unlikely that Ang-2 depletion or impaired tissue availability of the antibody could explain the lack of effect on plaque progression and stable plaque phenotype.

Addressing these issues with ECMO can often break the vicious and often fatal downward spiral of hypoxemia, hypercarbic (respiratory) acidosis, right heart failure, low cardiac output and the resulting metabolic acidosis from impaired oxygen availability at the cellular level.

The impaired cellular availability in vitamin B12 induces irreversible ER stress by greater acetylation of HSF1 through decreased SIRT1 expression, whereas adding vitamin B12 produces protective effects in cells subjected to ER stress stimulation.

To address here whether homocysteine had a part in the ER stress triggered by the impaired cellular availability of B12, we evaluated the effects of homocysteine itself on SIRT1 expression.

Furthermore, they also reported development of hepatic steatosis and insulin resistance in response to dietary copper restriction in rats, which was interpreted to suggest that impaired copper availability may be involved in the development of NAFLD.