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"What concerns me is the public's right to receive information will be impaired as a consequence of an unfortunate set of circumstances and an agency unable to focus".
For instance, if one biological process was weakened, another biological process could be impaired as a consequence and visa versa.
Immune cell function becomes impaired as a consequence of low tissue oxygenation and hypothermia.
[ 13] Nonetheless, the frequency of CCNA1 promoter hypermethylation in CC is high, whereas the function of TP53 in CC is usually impaired as a consequence of protein degradation induced by binding of the viral E6 protein.
The accumulated literature tends to assume that neuropsychological function is commonly impaired as a consequence of chronic methadone use justifying an abstinence agenda with premature termination of methadone treatment [ 29].
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However, it is not yet known which of these roles are the key in vivo neural functions of CLN3 or those that are impaired as a secondary consequence of the lack of CLN3 activity.
For example, it has been suggested that up to 1% of all children could suffer impaired neurodevelopment as a consequence of prenatal alcohol exposure, but solid evidence is lacking (2).
It is well known that the carnitine status in obese Zucker rats and other models of genetic and diet-induced obesity is markedly impaired and as a consequence several metabolic disturbances are induced [ 31– 31].
Patients with primary tumor locations in the lower extremity were expected to present lower lumbar spine Z-scores due to adhering to offloading recommendations or impaired gait as a consequence to tumor related pain and subsequently reduced physical activity levels.
No studies have examined whether this is related to impaired cardiovascular compliance as a consequence of loss of adaptive structural alterations, resulting from chronic uremia or hypertension.
Interestingly, Höglinger et al. [28] reported that the numbers of proliferating cells in the subependymal zone and neural precursor cells in the subgranular zone (SGZ) and olfactory bulb are reduced in the postmortem brains of patients with PD, suggesting that the generation of neural precursor cells is impaired in PD as a consequence of dopaminergic denervation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com