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While these findings demonstrate that the hippocampus is necessary for spatial working memory, it is not possible to determine whether lesions specifically impair working memory ability or whether lesions impair the ability to form or utilize a representation of space, or indeed, both.
Pre-clinical and clinical studies have shown acute stress may impair working memory and visuo-spatial ability.
Local infusion of the nicotinic antagonist methyllycaconitine (MLA) to block α7 nicotinic receptors and dihydro-β-erythrodine (DHβE) to block α4β2 nicotinic receptors into the basolateral amygdala and the ventral hippocampus have been found to impair working memory function, with no additive effects being observed.
Blockade of PFC 5-HT2A receptors has been found to impair working memory, which involves actions at both excitatory and inhibitory elements within PFC circuitry [27].
Although scarce, results from behavioral studies suggest that activating mMR and mGR impair working and may impair the consolidation of a fear memory [17], [40], [75].
Derangements of calcium-dependent protein phosphatase and kinase activity impair working memory [ 221].
Similar(48)
Because headache disorders are most troublesome in the productive years (late teens to 60 years of age), estimates of their financial cost to society are massive — principally from lost working hours and reduced productivity because of impaired working effectiveness and absentees during attacks[28].
Patients with schizophrenia display an array of cognitive symptoms, including impaired working memory capacity.
One core cognitive deficit is impaired working memory (WM) suggesting malfunctioning of the dorsolateral prefrontal cortex.
Figure 2 Percent of people with severely impaired working capacity among those with headache yesterday in nine European countries.
As McMorris et al. [10] suggested, moderate physical exercise seems to influence working memory and attention/perception tasks positively while high-intensity exercise improves attention/perception tasks but impairs working memory tasks.
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