Sentence examples for impair the normal functioning from inspiring English sources

Furthermore, perhaps the most challenging aspect is that these tools must not impair the normal functioning of the cell.

Together these results indicate that gradual accumulation of misfolded PMP22 and other undegraded pUb proteasome substrates impair the normal functioning of the proteasome, as detected by a chymotrypsin peptide reporter.

Consequently, such consumptive process can greatly impair the normal function of insulin and finally lead to IGT.

Second, the liver is a vital organ for protein synthesis and metabolic detoxification, and it plays a compensative role [ 33, 34] when metabolic dysfunction and inflammation impair the normal functions of muscle and fat.

Chemokines may contribute to SLE by recruiting immune and inflammatory cells to target tissues and by altering the normal trafficking and localization of certain populations of immune cells in the body; hence, they may impair the normal function of such cells.

The abnormal protein initially impairs the normal functioning of the brain and eventually kills brain cells.

Disruption of the integrity of the SC or TJ barrier impairs the normal functioning of the EPB.

Overexpression of dominant-negative LAR impairs the normal function of β-catenin-cadherin complex that regulates synaptic differentiation (Brigidi and Bamji, 2011).

Soluble oligomeric Aβ, in addition to aggregated α-syn, impairs the normal function of the proteasome [ 63, 68].

Tubulin-binding agents (TBAs) such as taxanes and Vinca alkaloids act by impairing the normal function of mitotic spindles.

Altered lipid distribution among cell membranes could lead to their accumulation in lysosomes, impairing the normal function of these organelles and thereby triggering pleiotropic cellular defects that might collectively contribute to Batten disease.