Our findings indicate that a life cycle exposure to MC-LR impairs the development and reproduction of female zebrafish by disrupting the transcription of related HPGL-axis genes, suggesting that MC-LR has potential adverse effects on fish reproduction and thus population dynamics in MCs-contaminated aquatic environment.
The lack of experimentally identified SDPs with supporting MSAs has impaired the development and evaluation of computational methods for predicting SDPs.
This problem impairs the development and implementation of effective evidence-based measures for infection control. 1 High-throughput methods using next-generation sequencing (NGS) are revolutionising bacterial genomics, providing sufficient resolution potentially to determine which cases within temporo-spatial clusters are likely to be related.
These results indicate that Tcra and Relb double deficiency in non-hematopoietic cells does not impair the development of DN and DP thymocytes, the T-cell compartment targeted by TEL-JAK2 in leukemogenesis [25].
Especially with participants from marginal, stigmatized or deviant populations the requirement for signed consent may be experienced as unwelcome, inappropriate or even coercive, and can impair the development of trust between researcher and participants [ 9, 28, 30, 85, 102, 124, 125].
ACE-i impair the development of kidneys, lungs, and skull ossification they cause intrauterine growth retardation; and even intrauterine demise [ 2].
So, living in an adverse environment could impair the development of primaries levels and it would impact in the development of superior levels (Stuss 1992).
When encountering patients with IDA in clinical practice, prompt iron supplementation should be considered to prevent possible psychiatric sequelae, because ID does impair the development of emotional regulation and cognition.
Several studies have shown that BPA can impair the development of mouse embryos and that this effect can be counteracted by Tamoxifen (an estrogen receptor modulator) [ 24, 61, 68].
In support of this view, administration of antioxidants such as N-acetyl cysteine, which abrogate ROS signalling or mutations in AMPK and SKN-1, impair the development of an adequate detoxifying response and abolish the DR-like state induced by the effects of metformin on bacterial metabolism.
If our current measurement tools cannot accurately measure preferences in patients with cognitive impairment, then measuring the preferences of impaired individuals will require the development and validation of new instruments, and in the interim these individuals should be identified and excluded from preference analyses.
