Sentence examples for impair the affinity of from inspiring English sources
These mutations impair the affinity of the epitope for the HLA molecule [7], [8], [9] or the interaction between the T-cell receptor (TCR) and the peptide-HLA class I complex [10], allowing the virus to replicate more efficiently.
However, sera from primigravid HIV positive women showed significantly higher kd, hence lower affinity, than sera from primigravid HIV negative women, indicating HIV infection to impair the affinity of VAR2CSA domaindomain specific antibodies (t-test, p = 0.0230, figure 3B).
As expected, both the S > R mutation and C-terminal 2ZF replacement completely impaired the affinity of their corresponding 7ZFPs.
The deletion of the terminal amino acids, the conjugation with HYNIC and/or the labelling with 99mTc could have impaired the affinity of the peptide for the receptor.
Based on the favorable hDAT-Tat binding mode (Fig. 1), it could be expected that mutations of His547 would eliminate a hydrogen bond between D-H547 and T-R49, which impair the binding affinity of Tat with hDAT, thereby diminishing Tat-induced inhibition of DA uptake.
However, we believe that it would be hard or impossible to probe the specificity of the interaction by targeted mutagenesis without concurrently impairing the general affinity of the polymerase for its primer/template substrate.
Therapeutic hypothermia below 35°C may impair brain tissue oxygenation through a left-shift of the oxygen dissociation curve, therefore enhancing the affinity of oxygen to hemoglobin, or by decreasing delivery of oxygen to the brain [ 21, 41].
Furthermore, pH >7.40 increases the affinity of haemoglobin for oxygen and may cause hypoxaemia, which further impairs cardiac function.
The affinity of the chimera for ferredoxin I (Fd I) was similar to that of the leaf isoform, although interprotein electron-transfer was partially impaired.
