These researchers found that impaired performances on tasks of short-term memory are explained by impaired serial order processing rather than impaired storage.
HBCP analysis detected impaired memory storage during delayed recall, whereas the original ADAS-Cog analytical method did not.
Moreover, IL-1β KO mice being high-fat fed (HFF) had lower mRNA levels of proinflammatory factors, increased expression of the adipogenic genes (Pparγ, Cebpα, Cebpβ, Fabp4) in adipose tissue and less hepatic steatosis compared with wild-type HFF mice, which suggests that IL-1β could impair fat storage and promote ectopic fat accumulation by limiting adipose tissue expandability (37).
This release of vasodilators from RBCs during hypoxia could be impaired during storage and/or sepsis.
During stimulation, impaired ACh storage becomes more pronounced leading to significant decrease in ACh release [13], [14].
Further, depletion of polyamines by culturing BMMCs with α-difluoromethylornithine (DFMO) caused aberrant secretory granule ultrastructure, impaired histamine storage, reduced serotonin levels and increased β-hexosaminidase content.
Dopamine is loaded into synaptic vesicles by a VMAT and pathogenic α-synuclein impairs dopamine storage in mammalian cell lines [32], [33].
Purified brain mitochondria of Pink1−/− mice showed impaired Ca2+ storage capacity, resulting in increased Ca2+ induced mitochondrial permeability transition (mPT) that was rescued by cyclosporine A. A subpopulation of neurons in the substantia nigra of Pink1−/− mice accumulated phospho-c-Jun, showing that Jun N-terminal kinase (JNK) activity is increased.
One of the mechanisms underpinning the increased cardiometabolic risk in metabolic syndrome is impaired Ca2+ storage in the sarcoplasmic reticulum and diastolic Ca2+ leak during hypersympathetic stimulation.
Aβ impaired calcium storage in mitochondria, altering neuronal function, as it is exported to the cytosol, together with other apoptotic factors (ProAp), such as cytochrome c.
