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This systemic response may impair progression of subsequent infections of neighboring mammary quarters [ 12, 17].
Ye and coworkers applied cell culture and molecular techniques to investigate the mechanism by which GLA may impair progression of breast malignancies.
These data are concordant with evidence from some preclinical studies that suggest that epoetin may improve cyto- and radio-sensitivity and impair progression of various tumours.
Consistent with our findings for hsl7 Δ, both hsl1 Δ and mih1 Δ, which also impair progression through the bud morphogenesis checkpoint, suppress the spt10 Δ growth defect, whereas a mutation (swe1 Δ) that promotes progression does not.
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Given that overexpression of hCdc14B impaired progression through mitosis, we next analyzed the mitotic phenotype caused by ablation of hCdc14B.
A decrease of cells in G2 phase could indicate impaired progression through the cycle and, therefore, explain the observed cell viability reduction.
Indeed, knockdown of HOXA1 in human fibroblasts impairs progression through G1 phase (Trapnell et al., 2013).
Depletion of CDC7 in cancer cells impairs progression through the S phase.
In summary, Trf1 deletion effectively impairs progression to full-blown carcinomas even in the absence of p53.
The swd mutation reduced exocrine pancreatic epithelial proliferation by impairing progression of cell division cycle and cell growth.
However, incompatibilities at other loci, like for example the HD locus, are perhaps impairing progression through the sexual cycle, as no dikaryotic mycelium or teliospores were observed.
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