Sentence examples for impair penetration from inspiring English sources

The optimised protocol was as follows: 0,1 μg (7,5 pmol) of siRNA was combined with 4,5 μl of Transit-TKO in 50 μl of H2O and incubated for 20 min at RT. Water was used as a solvent to minimize the size of the transfection particles and to prevent aggregates which may impair penetration through the inner limiting membrane into the retina.

Detailed studies of these mutants lead to the conclusion that the enhanced penicillin resistance of the wild type biofilm is due to a dual strategy: impaired penetration of the biofilm through its matrix, and rapid efflux of the antibiotic that still manages to penetrate.

Since telcagepant is a rather large, hydrophilic substance, this feature might impair its penetration through the blood-brain barrier into the CNS.

In Gram negative bacteria, the LPS constitutes the outer leaflet of outer membrane and may impair the penetration of antibacterial agents [6].

At nanoscale, the limited cell wall matrix porosity is considered an important factor that impairs cellulase penetration and accessibility to cellulose fibrils, therefore, contributing to biomass recalcitrance [ 16, 17].

Impaired drug penetration into hypoxic regions of tumours was thought to explain the poor prognosis, but recently an adaptive cellular response to hypoxia was demonstrated to reduce the cytotoxicity of many drugs.

It has already been demonstrated (van den Akker et al, 2000) that after topical application of He-ALA, the stratum corneum of the skin acts as a barrier impairing its penetration through the skin.

Given that the CSF HIV responded to therapy at least as effectively as plasma HIV, a relatively impaired CSF penetration of antiretroviral drugs seems unlikely to have influenced our findings.

Omission of six amino acids from the N-terminus did not significantly impair the cell penetration of the peptide while deletions at the C-terminus or in the middle of the transportan sequence decreased or abolished the cellular uptake.

This is because very high affinity interactions between antibodies and tumour antigens are predicted to impair efficient tumour penetration of the monoclonal antibodies and thus diminish effective in vivo targeting [28 32].

Previous studies have shown that very high affinity interactions of 109 M-1 between antibodies and tumor antigens may actually impair efficient tumor penetration of the monoclonal antibodies and thus diminish effective in vivo targeting [ 39].