During data cleaning and initial model evaluations, data records may be identified as erroneous (e.g., a sudden, transient decrease in concentration) and can be commented out if they can be justified as an outlier or error that impairs model development.
The flexibility of this loop impaired modeling of the Ala257-His258-Arg259 segmenthen ternarynary complex.
Another important consideration is that some of these variables may be endogenous and thus might require special treatment in order to not impair the model.
Previous studies showed that expression of REST might be impaired in models of polyglutamine disorders [32], [33].
The function of the ubiquitin-proteasome system (UPS) is impaired in models of neurodegeneration, and overexpression of chaperone proteins, such as those in the HSP70 family, leads to beneficial effects in many models of proteinopathies.
The delayed ossification persists into adulthood and is accompanied by impaired bone modeling and remodeling, resulting in short stature, increased bone mass, and gross morphologic abnormalities of the bones and joints, but normal bone strength.
Hypothyroidism disrupts growth plate chondrocyte differentiation leading to delayed endochondral ossification and linear growth, impairs bone modeling, and uncouples the processes of osteoclastic bone resorption and osteoblastic bone formation (43).
Introduce the child to various blind and visually impaired role models.
Class II mutations (represented by specific fusion genes in the original model) impair haematopoietic differentiation and subsequent apoptosis.
Interestingly, it has recently been observed that (on a behavioral level) acute stress does not impair so-called model-free reward learning, while more cognitively demanding model-based reward learning is more affected by acute stress when working memory capacity is lower [ 16].
