Habenular nuclei lesions have been shown to impair memory function.
Anterior temporal lobe resection controls seizures in 50 60% of patients with intractable temporal lobe epilepsy but may impair memory function, typically verbal memory following left, and visual memory following right anterior temporal lobe resection.
These results suggested that adjuvant regional radiotherapy in breast conservation therapy could impair memory function some months after completion of the therapy, and that the influence of the therapy on the impairment of memory function is partially mediated by elevation of plasma IL-6 levels.
Finally, cholinergic depletion of inferotemporal cortex, in this study, appears insufficient to impair memory functions dependent on an intact inferotemporal cortex.
Dementias such as Alzheimer's disease impair memory functioning, with short-term and explicit (declarative or conscious) memory usually considerably more affected than long-term and implicit (habitual or unconscious) memory [ 15, 16].
This demonstrated that exposure to the bloodstream of the aged mouse brought about impaired neurogenesis, electrophysiological evidence of impaired memory function and cognitive impairments in the young animals.
The term mild cognitive impairment (MCI) broadly defines an intermediate state of cognitive decline, predominately linked to impaired memory function, which is thought to be predictive of dementia, primarily AD.
In a recent report, PTPN3-deficient mice were also shown to have impaired memory function and motor learning, albeit that significant differences compared to controls were detected only in females [34].
Sleep difficulties, such as persistent insomnia, are associated with immune system changes [ 10], the development of diseases such as depression as well as impaired memory function and ability to concentrate and make decisions [ 11, 12].
Numerous studies show that chronic stress, in addition to impairing memory function, suppresses proliferation, survival and differentiation of new neurons in the adult DG (Wong and Herbert, 2004; Mirescu and Gould, 2006; Kirby and Kaufer, 2009).
Previous neuropsychological and functional MRI studies have shown that left and right TLE patients may have impaired memory function, which is usually material-specific, due to the underlying pathology and ongoing disease (Helmstaedter et al., 1997, 2003; Gleissner et al., 1998; Golby et al., 2002; Powell et al., 2005).
