Sentence examples for impair its effect from inspiring English sources

An act of Congress, they held, does not trump the Constitution; such a law "cannot control [the Constitution's] meaning, or impair its effect, but must be construed and executed in subordination to its provisions".

Therefore, the ubiquitin/SUMO modification of VHL allows for precise regulation of VHL nucleocytoplasmic trafficking, and disruption of this process can impair its antitumor effects.

Higher levels of high density lipoprotein (HDL) subfractions HDL3-chol and particularly HDL2-chol protect against cardiovascular disease (CVD), but inflammation reduces the HDL level and may impair its anti-atherogenic effect.

Since the APOA5 −1131T>C polymorphism is located in the promoter region of APOA5, it may alter the APOA5 expression and impair its function, and cooperative effects between APOA5 polymorphisms cannot be excluded.

Likewise, native proNGF, in cultures containing the broad spectrum MMP inhibitor batimastat to impair its degradation, had a similar effect on neurite growth from P3 SCG neurons (Fig. 2M).

If the control construct were to deplete R15 from its normal location and if this were to impair its enzymatic activity, the observed effect of mDia2 induction would be minimized since eIF2α phosphatase activity would have been impaired similarly by the GFP-R15B 1-146 constructonstruct (expressed at similar levels to the mDia2 construct on western blots).

Studies in humanised resistin mice suggest that, even though the site of resistin production differs between species, human resistin exacerbates inflammation in white adipose tissue and contributes to IR, thereby impairing its normal effects [ 16],[ 17].

The direct effect of adenine crystals on renal tubules and interstitium impairs its use on studies of effects of CKD-MBD therapy on CKD progression.

We thus conclude that CtpSE277R impairs polymerization independently of its effect on activity.

Although acetazolamide increases wild-type chloride currents in vitro, ClC-1 mutations can impair such effect and may limit its clinical efficiency, especially in recessive carriers.

It is shown that this may substantially impair network performance but that its effect may be countered by introducing a simple retrofit option of flow measurement and control.