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The macrophages release inflammatory molecules that are thought to impair insulin activity.
Research has shown that low levels of Mg may impair insulin sensitivity or function.
Our results indicate that E23K could impair insulin sensitivity, thus predisposing E23K carriers to insulin resistance.
However, there is some evidence that TFA could impair insulin sensitivity compared to unsaturated fat in insulin resistant or diabetic individuals.
These data established that short telomeres significantly impair insulin release.
FFA impair insulin signaling in β-cells in part via activation of ER stress [16], [24].
Specifically, deficiencies in the SNARE complex proteins have been shown to impair insulin secretion [17].
To our knowledge, this is the first study showing that the same risk alleles can jointly impair insulin secretion and elevate FPG level.
With the exceptions of the diacylglycerides and ceramides, the mechanisms through which lipid species can impair insulin signaling remain poorly understood [4], [5], [6], [7], [8].
As TNF-α can impair insulin signal pathways and lead to B-cell destruction, elevated TNF-α is considered playing a central role in the development of T2DM.
Many drugs can impair insulin secretion.
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