Glucocorticoids impair glucose tolerance by inducing insulin resistance.
Lumbar spinal stenosis (LSS) can hinder a patient's physical activity, which in turn can impair glucose tolerance and body weight regulation in patients with type 2 diabetes mellitus (DM-2).
Furthermore, since pharmacologic activation of AMPK can reverse the glucose dependence of Akt-transformed cells, the data also suggest that clinically utilized AMPK activators, such as metformin, might enhance tumor cell survival when such drugs are utilized concomitantly with experimental agents that impair glucose utilization.
We show, in a genetically defined model, that short telomeres are sufficient to impair glucose homeostasis.
Surprisingly, and in accordance to a recent study, AIF deficiency in Hq mutant mice did not impair glucose tolerance.
These data, in two independent genetic backgrounds, indicated that short telomeres impair glucose tolerance because of defective insulin release.
To test whether short telomeres impair glucose homeostasis, we studied late generation CAST/EiJ mice that are heterozygous null for telomerase RNA, mTR+/−, and have short telomeres (Figure S1A).
In healthy people even short-term sleep restriction or experimentally induced disturbed sleep have been shown to impair glucose tolerance [4], [5] indicating that sleep might be pivotal for metabolic homeostasis.
Thus, while the high-fat fed wild-type and ob-norm animals have similar fasting hyperglycemia and hyperinsulinemia, the ob-norm animals have an additional defect in glucose metabolism that is revealed by glucose challenge suggesting that their relative leptin deficiency may further impair glucose metabolism of DIO mice.
These data indicate that even low-dose glucocorticoids may impair glucose tolerance when administered chronically.
Some types of decaffeinated coffee may acutely impair glucose metabolism but less than caffeine.
