Sentence examples for impair gene expression from inspiring English sources

With consideration for potential promoter interruption and the demonstrated efficacy of intronic insertions, 61%% of mapped T-DNA insertions should impair gene expression or function.

This analysis suggests that DNA methylation is closely associated with repressive chromatin marks at the PPARG promoter to impair gene expression in CRC cells.

This well-described transcription factor in the brain has the potential to enhance or impair gene expression, depending on the concomitance of a C/EBP binding site [46] [49].

We focused attention on these islands as we would expect them to be unmethylated in young subjects yet contain many potential sites for age-related increases in methylation that may impair gene expression.

Importantly, impaired gene expression by GR interference may increase infection susceptibility, which was recently found in few cases of RU486-treated women [23].

Thus, we demonstrate cyclosporine treatment of human hepatoma cells to significantly reduce DNA-binding of HNF4α to AGT and AGTR1 at gene specific promoters to cause impaired gene expression.

Indeed, RFC-1 has impaired gene expression and protein levels in the diabetic retina [ 35].

Unfortunately, RNA derived from formalin-fixed, paraffin-embedded (FFPE) material is considerably fragmented and chemically modified, often impairing gene expression measurement using standard procedures.

Impaired gene expression in the knock-out mutant was confirmed using RT-PCR (with primers spanning the respective T-DNA insertion sites) and northern-blot analyses.

Although both NDEA and HFD feeding caused structural injury and impaired gene expression in ways that could cause insulin/IGF resistance in the brain, their specific effects were not identical.

These drawbacks are important since the inaccurate localization of DNA in the nucleus impairs gene expressions (Meldi and Brickner, 2011).