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Patients recovering from critical illness may show persisting organ dysfunction that could impair functional status (physical, social, emotional function) with an associated reduced health-related quality of life (HRQOL).
Meanwhile, we distract ourselves from our mortal terror – which would impair functional human activity were it allowed free rein – by working hard, staying busy, shopping and entertainment.
This method however does not allow to achieve single phase and sufficient chemical homogeneity that could impair functional properties of materials [7, 8].
It can also increase the risk of pulmonary complications and impair functional ability, which may increase length of hospital stay and the associated costs.
Complications impair functional and neurological outcome [2], [4], [8].
In contrast, the multiple infections experienced with increasing age in high malaria transmission areas may generate a more complex antibody repertoire, including a subset of antibodies that interfere with or impair functional inhibitory activity.
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ICU-AW is associated with short-term and long-term physical impairments and impaired functional status [ 1].
It is possible, therefore, that NRP1 antagonists and siRNAs could indirectly affect tumour cell function by impairing functional signalling mediated via other receptors such as c-Met.
Specifically, loss of function of limb muscles impairs functional independence and loss of diaphragm function is implicated in respiratory failure (Murphy et al., 2011).
Then, postoperative radiotherapy (RT) improves survival without impairing functional status or neurocognitive functions, compared with best supportive care only following resection.
Patients who survive sepsis often have severely compromised organ function that may result in persistent physical and psychological symptoms (dyspnoea, fatigue and depression), impaired functional status (physical, social and emotional function) and reduced health-related quality of life (HRQoL) [ 6].
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