Sentence examples for impair efficient from inspiring English sources

This is because very high affinity interactions between antibodies and tumour antigens are predicted to impair efficient tumour penetration of the monoclonal antibodies and thus diminish effective in vivo targeting [28 32].

Recent investigations on the α-enolase of S. mutans [25] suggest that variations of this internal binding motif exist (FYDNG VY), which may impair efficient plasminogen binding and activation.

Previous studies have shown that very high affinity interactions of 109 M-1 between antibodies and tumor antigens may actually impair efficient tumor penetration of the monoclonal antibodies and thus diminish effective in vivo targeting [ 39].

There is evidence in both yeast and mammalian cells that INO80 functions to promote resection 9151819 19, and although the defect in mammalian cells depleted of INO80 is relatively mild, this may be sufficient to impair efficient HR.

This may theoretically impair efficient binding of RV to the bronchial epithelium and thereby lead to a reduction in virus loads, as demonstrated by a previous study which reported reduced virus loads following influenza virus challenge in MUC5AC-overexpressing mice [ 53].

One of the main issues that currently impair efficient development of structure OA modifying therapies is the low sensitivity of the plain X-ray, requiring long-term studies to show a significant difference between placebo-treated and active-drug-treated patients.

However, expression of a C-terminally deleted mutant lf ICAM-1 severely impaired efficient TEM.

This is accompanied by a reduced expression of pointed, showing that the lack of ESCRT-0 activity specifically impairs efficient FGF signalling in ASP cells.

Moreover, the expression of EGFP-Syk Y323F interfered with proper cell polarization and it impaired efficient migration of dHL-60 cells.

Similarly, nuclear export sequences (NES) have been found in ataxin-7 [32] and huntingtin [33] and it was shown that polyQ expansion impairs efficient nuclear export of these polyQ-containing proteins [32], [34].

Breeding ranges of Phoebastria albatrosses are further constrained by confinement within a single ocean basin, with the aerodynamic performance of short-tailed albatrosses likely preventing crossing through areas of low wind speed and low productivity (e.g. central Pacific) and the aerodynamic performance of waved albatrosses potentially impairing efficient use of windy areas.