Sentence examples for impair efficacy from inspiring English sources

The replacement of C by O and F by X does not appear to impair efficacy.

For established drugs, a widespread move away from surface area based dosing is likely to need randomised trials to confirm that so doing does not impair efficacy or result in increased toxicity.

Those liabilities, taken together, can result in unwanted safety and toxicity issues, as well as impaired efficacy.

As such, bioprocessing has become a limiting factor in the downstream use of hMSC as non-uniform samples and variation in function impairs efficacy, outcome and application of these advancements.

Moreover, the proportion of subjects receiving all scheduled vaccinations was as low as 60% in one trial.[ 21] Choosing a target quit date shortly after the first booster injection might also have impaired efficacy, as peak antibody titres were only observed following several vaccinations.

Mitochondrial impairment or insufficiency has been reported to impair the efficacy of SCNT [ 52].

Activation of these DNA repair proteins in CSCs can impair the efficacy of ICL agents.

Ofloxacin did not appear to impair the efficacy of BCG during 12 mo after treatment.

In our case, we did experience leakage of peritoneal fluid from the exit site, which did not impair PD efficacy.

In our animal model, vatalanib reduced the drug uptake into the tumor cells, which may impair the efficacy of any targeted therapies.

The differentiation capabilities of mesenchymal stem cells (MSCs) compromise with age and with in vitro passages which could impair the efficacy of cell therapy and tissue engineering.