Significant associations were also detected in two SNPs (rs2229741 and rs4986938) in MM individuals, although their significance was not less than 0.01 and due to our relatively small sample sub population for MM samples, we may have impaired capability to detect true associations for this population.
Compared to AMPK complexes immunoprecipitated from cells without heat shock, complexes from heat-shocked cells exhibited markedly impaired capability to phosphorylate recombinant ACC1 proteins in vitro even in the presence of AMP (Fig 5B).
Furthermore, due to its high surface heat flux and low velocities under natural circulation in any post-LOCA scenario, three effects impair the capability of turbulent gas flow to remove heat from the GFR core, namely: (1) acceleration effect, (2) buoyancy effect and (3) property variation.
(B) Filtration treatment did not impair the capability of the AMV reverse transcriptase to perform their function in different concentrations.
Consistently, the function test showed that filtration treatment did not impair the capability of the AMV reverse transcriptase to perform their function in different concentration (Fig. 2B).
Expression of the transfected DJ-1 constructs was confirmed by immunoblotting, supporting the finding that the familial mutations impair the capability of DJ-1 to antagonize aSyn dimerization/oligomerization.
Since AP-1 mediates the action of LPS, TCDD would thus impair the capability of LPS to drive the switching of the transcriptional gene circuit that underlies B-to-plasma cell differentiation, thereby suppressing the formation of antibody-secreting plasma cells [ 6].
Biliary obstruction itself disadvantages the immune system and impairs its capability to fight infection, by impairing the function of certain immune system cells (neutrophil granulocytes) and modifying the levels of immune hormones (cytokines).
Further research is then required in ToM and schizophrenia to see whether the presence of schizophrenia itself is enough to impair ToM capabilities or whether ToM impairment is due, instead, to presence of particular symptoms or presence of some general neuropsychological deficit.
Although ESCs can tolerate DNA hypomethylation without impairment of cell proliferation (Tsumura et al., 2006), hypomethylation nonetheless impairs the capability of ESCs to achieve, and maintain a differentiated state (Feldman et al., 2006; Jackson et al., 2004; Sinkkonen et al., 2008).
Open image in new window Figure 2 Filtration decreases the miRNA contents without impairing the capability of the AMV reverse transcriptase.
