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Published on 20 February, the enhanced eLife article describes an attempt to replicate a 2012 paper2 about how a gene that is often mutated in cancer cells impacts the expression of other genes.
In doing so, our work characterizes targetable molecular pathways mediating well-established malignant behavior in diffusely infiltrating astrocytic gliomas, while also revealing discrete examples of how mutational disruption of chromatin regulation impacts the expression of tumor-specific biology.
The findings from this study suggest two things: first, that increased ERα in the BST decreases social affiliation and second, that altering ERα in different regions of the social neural circuit differentially impacts the expression of social behavior.
Our finding that Gs-alpha impacts the expression of transcription factors important for ES cell pluripotency is not unexpected considering the diverse roles of cAMP in multiple cell types.
Using this rationale, we examined the impact of signaling through Gs-alpha on ES cells and report for the first time that the Gs-alpha pathway is present, functional in ES cells, increases ES cell proliferation, and impacts the expression of transcription factors important for ES cell pluripotency.
Thus, we next investigated whether L.obtusiloba extract impacts the expression of VEGF and HIF-1α in HCC cell lines.
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Second, depletion of OLE1 had little impact on expression of the HSPs at 42°C.
Both the elastic modulus and composition of the scaffolds impacted the expression of endothelial and smooth muscle cell genes.
After 10 weeks of continuous expression, these ribozymes, like siHUNT-2, negatively impacted the expression of a subset of genes in the striatum.
These findings suggest that mutations in the 3′UTR might impact the expression of MeCP2 (McGowan and Pang, 2015).
The results also point to additional factors that may impact the expression of biological rhythms in bipolar disorder.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com