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The findings from this study suggest two things: first, that increased ERα in the BST decreases social affiliation and second, that altering ERα in different regions of the social neural circuit differentially impacts the expression of social behavior.
Our finding that Gs-alpha impacts the expression of transcription factors important for ES cell pluripotency is not unexpected considering the diverse roles of cAMP in multiple cell types.
Using this rationale, we examined the impact of signaling through Gs-alpha on ES cells and report for the first time that the Gs-alpha pathway is present, functional in ES cells, increases ES cell proliferation, and impacts the expression of transcription factors important for ES cell pluripotency.
Thus, we next investigated whether L.obtusiloba extract impacts the expression of VEGF and HIF-1α in HCC cell lines.
We have additionally provided further evidence that AtNHX1 impacts the expression of other components of the response of Arabidopsis to stress.
It also remains unclear whether FAK activity within a tumor spheroid impacts the expression of target proteins selectively required for three-dimensional or anchorage-independent cell survival.
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These findings suggest that mutations in the 3′UTR might impact the expression of MeCP2 (McGowan and Pang, 2015).
The results also point to additional factors that may impact the expression of biological rhythms in bipolar disorder.
Both the elastic modulus and composition of the scaffolds impacted the expression of endothelial and smooth muscle cell genes.
After 10 weeks of continuous expression, these ribozymes, like siHUNT-2, negatively impacted the expression of a subset of genes in the striatum.
That is, the aforementioned diverse mutations in signaling pathways and networks would ultimately impact the expression and activity of metabolic enzymes, thereby enabling tumor cells to adopt specific bioenergetic features fit for their unique environment.
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