The results presented here were consistent with the requirement for this mutation but also demonstrated that other changes [ 28] had considerable impacts on the function of the enzyme.
In addition to the decreased expression levels, conditions in failing heart negatively impacts on the function of the remaining SERCA2a (reviewed in Kratlian & Hajjar, 2012).
It would be interesting to establish whether the effect of MED13 on cardiac metabolism impacts on the function of cardiomyocytes and why MED13 differentially affects the cardiac muscle and peripheral organs.
Bleasel and colleagues [ 93] have tested the hypothesis that ABCA8 expression is associated with the disease process of MSA through involvement in the early disruption of myelin processing with subsequent impacts on the function and homeostasis of the key disease proteins α-syn and p25α.
More data in humans is needed to assess the effects of immunosenescence on the functions of DCs, NK cells, and neutrophils as findings thus far are heterogeneous; however, it is likely immunosenescence impacts on the function of these cell types as well.
Immunosenescence impacts on the function of the innate as well as the adaptive immune system (reviewed in Panda et al., 2009; Ademokun et al., 2010; Agrawal & Gupta, 2011; Arnold et al., 2011; Mahbub et al., 2011; Weinberger & Grubeck-Loebenstein, 2012; Scholz et al., 2013).
