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Further work on whether deformable MR-US registration impacts on efficacy is required.
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In particular, whether or not an agent binds one or all VEGF-A isoforms appears to have a substantial impact on efficacy.
However, there is concern that the combination of chemotherapy with more than one targeted agent can be associated with reduced tolerability and no beneficial impact on efficacy [ 8, 9].
The acceptable ranges for CQAs are set based on their potential impact on efficacy and safety/immunogenicity.
The choice has a real impact on efficacy and toxicity Hypo- or hypertonic, high or low chloride and sodium level, lactate or bicarbonate buffer, glucose containing or not.
Recent reports have demonstrated that SIR is safe for patients with HCC, but the impact on efficacy of venous thrombosis is unknown.
By studying the different study designs and comparators in both settings, we were able to demonstrate their impact on efficacy endpoints.
The relative immunity which is the likely cause of the different impact on efficacy between pregnant adults and children does not seem so marked for gametocytes.
Measures that increase the average immune response (e.g. more active adjuvants or altered vaccination regimens) have a bigger impact on efficacy for vaccines that have a narrow fold range of responses, than vaccines that have a broad fold range.
The new drug may have no impact on efficacy.
Moderators are characteristics of subjects before treatment that have an impact on efficacy or tolerability.
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CEO of Professional Science Editing for Scientists @ prosciediting.com