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These data suggest that Dis3KD effects on early RNA metabolism may be accentuated by impacting the expression of Rrp6 or exosome subunit RNAs.
Those results point to a cis-acting variant impacting the expression of PARK2 in the liver of divergent chicken lines, emphasizing the potential causal status of this gene for adiposity.
Additionally, the CREB coactivator CBP/p300 is mutated in several human cancers, with loss of CBP/p300 histone acetyltransferase activity potentially impacting the expression of several tumour suppressor targets (Iyer et al, 2004).
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Both the elastic modulus and composition of the scaffolds impacted the expression of endothelial and smooth muscle cell genes.
In doing so, our work characterizes targetable molecular pathways mediating well-established malignant behavior in diffusely infiltrating astrocytic gliomas, while also revealing discrete examples of how mutational disruption of chromatin regulation impacts the expression of tumor-specific biology.
After 10 weeks of continuous expression, these ribozymes, like siHUNT-2, negatively impacted the expression of a subset of genes in the striatum.
Published on 20 February, the enhanced eLife article describes an attempt to replicate a 2012 paper2 about how a gene that is often mutated in cancer cells impacts the expression of other genes.
These findings suggest that mutations in the 3′UTR might impact the expression of MeCP2 (McGowan and Pang, 2015).
The results also point to additional factors that may impact the expression of biological rhythms in bipolar disorder.
Topology is interesting because single nucleotide variations (SNV), point mutations, and insertions or deletions (indels) can indirectly impact the expression of a distant gene by rearranging the genetic architecture [66].
We next asked whether seizures impacted the expression of CXCL12 in the hippocampus.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com