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We demonstrate that factors associated with the risk of death impact on bias differently from factors associated with other forms of attrition; the former impacting on both the study cohort and the target population, and the latter impacting on the study cohort alone.
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This finding supports the notion that, in this study, the multiple regression findings are valid and that the various sources of error do not seriously impact on the study validity.
Dose response relationships are often atypical and this should impact on the study design.
The definition of the comparison groups and the length of the observation period may impact on the study conclusions.
Investigators may perform ancillary care procedures if they are minor and will not impact on the study protocol.
First, patients were re-randomised from the acute studies even if their initial response had been to placebo, and this may have impacted on the study findings.
Thus: Simple (one-way) sensitivity analysis was used on parameters that as demonstrated elsewhere [ 12, 18, 19] might impact on the study results.
First, total blood loss was greater in the NS group than in the RL group, which may impact on the study findings.
In addition, there was missing data and limited demographic data in the records that may also have impacted on the study findings.
Therefore, whilst the full range of viewpoints may not be represented this is unlikely to have impacted on the study's findings.
We hypothesized that the testing condition would impact on the study outcomes since walking requires different muscular activity compared to static standing [ 30].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com