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Enabling and restricting factors impacting on the functioning of the CAB were identified.
"UNICEF is calling for more support from the international community," says UNICEF Representative in Madagascar Bruno Maes, "to ensure that this essential programme for child survival and development can continue in a context where the socio-political crisis is deeply impacting on the functioning of the health system".
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There are several plausible mechanisms by which a 3′UTR variant could impact on the functioning of a gene.
3 Moreover, the repeated stretch and the compression of airway epithelial cells at high flow rates may negatively impact on the functioning of the epithelial cells.
Therefore, COMT activity might indirectly impact on the function of PEMT (and vice versa) due to competition for SAM.
Intronic sequence expression between exon 1 and exon 2 may impact on the function of CD74, because it is located within the trimerisation domain of the protein.
For highly abundant proteins, shifts in their pI can impact on the function of organs that interact with them.
In addition to the decreased expression levels, conditions in failing heart negatively impacts on the function of the remaining SERCA2a (reviewed in Kratlian & Hajjar, 2012).
This is not surprising as both C1q and C3 have been demonstrated to impact on the function of antigen presenting cells and T cells in vitro 12– 12.
Both C1q and C3 have been shown to impact on the function of antigen presenting cells and T cells in vitro and in vivo 12– 12.
The result indicated that these genes possess central and essential functions and nonsynonymous mutations impacting on the genes function have been removed by purifying selection [ 65].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com