Exact(2)
Magnesium is also important for the fidelity of DNA replication, impacting cell cycle and apoptosis [ 61].
It has been documented that CD20 regulates B cell proliferation by impacting cell cycle progression in these cells [22], [33].
Similar(58)
Our studies provide evidence by which SUMO modification of G9a influences the chromatin environment to impact cell cycle progression.
CD20 is thought to be a regulator of transmembrane Ca2+ conductance which indirectly impacts cell cycle progression and proliferation of B cells [11], [38].
Given these effects, we asked whether expression of NES-hTERT would also impact cell cycle progression of telomerase-positive cancer cells.
Mir-17, -20a, and -106b downregulate a common set of pro- and anti-proliferative target genes to impact cell cycle progression of USSC and increase intracellular activity of E2F transcription factors to govern G1/S transition.
Notably, the Myc-associated zinc finger protein was detected in the transgenic cell cycle gene set (Tables S4 and S5), which indirectly suggests that Myc impacted cell cycle regulation in transgenic cells, but not or to a lesser extent in tumor cells.
Complete lack of mitochondrial hTERT in SQ20B and LNCaP cells could potentially drive the degree of mitochondrial impairment, which is already noteworthy in cancer cells [58], to a limit that impacts cell cycle regulation either through increased reactive oxygen species (ROS) and DNA damage, changes in oxygen utilization and/or energy production.
Intriguingly, Cdc42 overexpression does not impact cell cycle progression to drive increased branching.
Apart from DNA repair, the DNA damage response also impacts cell cycle progression, cell survival, cell senescence and the cellular transcription programme [71].
In both treatment groups, similar distributions were observed for CRY2+ and CRY2- cell populations, indicating that reduction of CRY2 alone is not sufficient to significantly impact cell cycle regulation.
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