Your English writing platform
Discover LudwigExact(1)
Diet also impacted translation (17%; mostly ribosomal proteins) and signalling (17%).
Similar(59)
Proteomics studies have shown that a single miRNA impacts translation of hundreds of mRNAs [21], [22].
While there is currently no evidence to conclusively demonstrate that these variants may impact translation dynamics for complex I (and thereby alter the bioenergetic system of the neural and vascular retina), our results provide a reasonable basis for examining this possibility.
In turn, this should impact translation rates and any functions that depend on mtDNA-encoded proteins.
This negatively impacts translation efficiency and hinders the rate of protein production.
The authors suggest that synonymous mutations impacting translation efficiency may play a significant role.
More specifically, we have designed libraries systematically varying multiple sequence properties known to impact translation efficiency in E. coli.
As these events could impact translation, we checked whether poly(A) site shifts occurred in Clc-1 mRNA in Mbnl1 ΔE3/ΔE3/Mbnl3 ΔE2 skeletal muscles.
These results, along with our previous analysis of ATG31 protein levels demonstrate that, as expected, 5′extension of mRNAs created by disruption of adjacent Pol III complex formation impacts translation of the coding sequences.
Variations involving skipped exons tended to impact translations in a similar manner to unspliced introns and alternate acceptors/donors, although they occur much less frequently, with only 130 examples currently identified.
This mutation had no effect on MYCN translation from MYCNΔ1 b mRNA but significantly impacted the translation from MYCN mRNA.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com