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Both the elastic modulus and composition of the scaffolds impacted the expression of endothelial and smooth muscle cell genes.
After 10 weeks of continuous expression, these ribozymes, like siHUNT-2, negatively impacted the expression of a subset of genes in the striatum.
We next asked whether seizures impacted the expression of CXCL12 in the hippocampus.
As shown in Figure 7D, both BCR/ABL fusion proteins abolished the expression of PAX5 and strongly reduced that of E2A, in contrast to p40ABL/BCR and p96ABL/BCR, neither of which strongly impacted the expression of E2A or PAX5 alone.
We next examined whether the FOXA1 level impacted the expression of AR target genes in EC cells.
In addition, selective activation of ERβ might have impacted the expression of ERα in the AVPV, and our subsequent observations, therefore, reflect changes in ERα activity [ 72].
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In doing so, our work characterizes targetable molecular pathways mediating well-established malignant behavior in diffusely infiltrating astrocytic gliomas, while also revealing discrete examples of how mutational disruption of chromatin regulation impacts the expression of tumor-specific biology.
Published on 20 February, the enhanced eLife article describes an attempt to replicate a 2012 paper2 about how a gene that is often mutated in cancer cells impacts the expression of other genes.
These findings suggest that mutations in the 3′UTR might impact the expression of MeCP2 (McGowan and Pang, 2015).
The results also point to additional factors that may impact the expression of biological rhythms in bipolar disorder.
Topology is interesting because single nucleotide variations (SNV), point mutations, and insertions or deletions (indels) can indirectly impact the expression of a distant gene by rearranging the genetic architecture [66].
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