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It is conceivable that the introduction of a charged (R) or a bulky residue (W) in place of G34 might impact the accessibility or activity of enzymes that target K36 or alter the conformation of the tail leading to changes in nucleosomal packaging that affect the binding of histone readers to H3K36me3.
Another feature that may explain the therapeutic effectiveness of implantation therapy in the distal esophagus is the remodeling of the esophagogastric junction opening anomalies recently described in GERD patients compared to normals.28 This would negatively impact the accessibility and the volume of gastric reflux entering the esophagus.
The effect of different health insurance schemes differed according to their financing regimes, which impacted on the accessibility of health services.
Cognitive impairment, physical disability and social isolation can also impact on the accessibility of treatment and have to be considered along with the biological changes with ageing.
This is why measures aimed at influencing prescriber behavior can substantially impact the financial accessibility of the Belgian health care system.
"It seems that the measure will mainly benefit record producers and not performing artists, will only have a very limited effect for most of the performing artists" and "will have a negative impact on the accessibility of cultural material" for consumers.
The Borders Railway project will make a real impact on the accessibility of our Milton Road and Midlothian campuses.
While computing power has grown with Moore's law, the availability of cloud based resources have had a dramatic impact on the accessibility of the computing power.
Legal marijuana in Canada will undoubtedly have an impact on the accessibility of pot in America, its largest trading partner with whom it shares a 5,500 mile-long border.
This might result not only in the withdrawal of more hospitals from providing care but also in affecting many more patients and hence having a stronger impact on the accessibility of hospital care on a population level in most parts of Germany, at least for the concerned interventions.
However, it is important to evaluate if or to what degree high quality referral letters, according to the results of this study, improve the outcomes for patients and the organisation, and if they have a positive impact on the accessibility of specialised health care for the patients most in need.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com