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To examine if DKK1-mediated inhibition of canonical Wnt signaling in TECs, impacted T cell development, total thymocyte numbers were counted.
The major focus of this study was to better understand the consequences of effector T cell entry into the tumor microenvironment, with a specific emphasis on how this impacted T cell maturation and cytolytic activity.
Next, we expanded the breadth of the study by investigating whether pUL135 impacted T cell recognition.
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To assess to what extent DNA asymmetry impacted T-DNA integration, the occurrence of CG and AT skews contexts at T-DNA insertion sites were also analyzed in gene terminator, gene coding and intergenic regions.
Hence, GC therapy of EAE impacts T cells via the transactivating as well as the transrepressing function of the GR.
In addition to its effects on inflammatory cells, mosquito saliva also impacts T cell populations, increasing mortality and decreasing division rates [11].
Hence, in the present study we focused on long-term assays of MBP-specific T cells, in order to address how PP14 may impact T helper subset polarization per se.
The movement of proteins during T cell interaction with antigen presenting cells impacts T cell function.
Adenosine can impact T cells activity by increasing of intracellular cAMP levels [ 56].
How the tumor microenvironment will impact T cell plasticity remains to be investigated.
While the precise function of the DPC is disputed, formation of the DPC does appear to impact T cell activation.
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