Sentence examples for impacted pathways from inspiring English sources
The pathways were ranked according to p values, with the most significantly impacted pathways are shown on the top.
Nearly half of these 10 commonly impacted pathways (File S1), belong to amino acid metabolism, suggesting that amino acid metabolism plays a critical role in the compounds' effects which is consistent with Gene Ontology analysis.
The most highly impacted pathways (p < 0.05) populated by genes differentially expressed (also p < 0.05) are listed in Table 1.
Within the molecular function (GOTERM_MF-FAT) category, among the top ten impacted pathways were NAD+diphosphatase activity and nucleotide diphosphatase activity which were activated (Fig. 6).
One feature of this software is the use of statistical algorithms to determine the most highly impacted pathways, considering the number of input genes compared to total genes in a given pathway; a commonly used hypergeometric over-representation approach.
IL-8, COL1A1, COL1A2, THBS2, SPP1, COL6A3 and SFRP4 were mapped to several highly impacted pathways: leukocyte transendothelial migration, extracellular matrix receptor interaction, tight junction, epithelial cell signaling in H. pylori infection, TGFβ signaling pathway, toll-like receptor signaling and Wnt signaling (Table 5).
In particular, the Nrf2-mediated oxidative stress response pathway, which has recently been found to play an important role in cancer prevention, was the most significantly impacted pathway (p = 4.55×10−9).
As it was the most significantly impacted pathway in this analysis (p < 0.001), the cell-cycle pathway was selected for further phenotypic validation.
Significantly, we find that Set2 loss leads to altered chromatin structure and inappropriate resection in G1 at break sites, which ultimately impacts pathway repair choice.
Because segmentation involves complex cross-talk between several signalling pathways, we analysed how rbpj derepression impacted these pathways.
These two impact pathways work together.
