Sentence examples for impacted pathway from inspiring English sources

In particular, the Nrf2-mediated oxidative stress response pathway, which has recently been found to play an important role in cancer prevention, was the most significantly impacted pathway (p = 4.55×10−9).

As it was the most significantly impacted pathway in this analysis (p < 0.001), the cell-cycle pathway was selected for further phenotypic validation.

With the aim to reach a better understanding about the biological relevance of each pathway, the present analyses are also focused on the significant biological processes, molecular functions, cellular components, and domains and important sites of proteins (GO-Interpro) within each significantly impacted pathway.

The pathways were ranked according to p values, with the most significantly impacted pathways are shown on the top.

Nearly half of these 10 commonly impacted pathways (File S1), belong to amino acid metabolism, suggesting that amino acid metabolism plays a critical role in the compounds' effects which is consistent with Gene Ontology analysis.

The most highly impacted pathways (p < 0.05) populated by genes differentially expressed (also p < 0.05) are listed in Table 1.

Within the molecular function (GOTERM_MF-FAT) category, among the top ten impacted pathways were NAD+diphosphatase activity and nucleotide diphosphatase activity which were activated (Fig. 6).

Significantly, we find that Set2 loss leads to altered chromatin structure and inappropriate resection in G1 at break sites, which ultimately impacts pathway repair choice.

Because segmentation involves complex cross-talk between several signalling pathways, we analysed how rbpj derepression impacted these pathways.

The model is based on the impact pathway method.

Externality of fusion energy is analyzed by CO2 emission, impact pathway of tritium, rad-waste, and some social impacts.