Patients' perceptions of disease severity (depression and functional decline) were the strongest determinants, whereas, physician-rated multimorbidity (morbidity burden) also impacts independently on HRQOL - more than findings in previous studies suggest.
Confounding by lifestyle factors (obesity, smoking, alcohol consumption) both increase breast cancer risk (Thun et al, 1997; Sonnenschein et al, 1999; McDonald et al, 2002), and contribute to general health deterioration, likely to impact independently on breast cancer prognosis (Sjol et al, 2003).
Or that the F.D.A. has never studied the impact independently, but instead accepts Monsanto's studies as gospel.
If analysing subgroups of patients with malignant or benign tumours in view of the factor age, the criterion age under 30 years maintained the negative impact independently of the differentiation of the tumour.
Considering that these two ingredients may work independently as well as inter-dependently, the three treatment arms allow an investigation not only to determine the effectiveness of the combined psychoeducation and peer-support treatment condition, but also of how each ingredient impacts independently on particular participants' outcomes, minimising any contamination [ 26, 27].
There is growing evidence indicating that patellofemoral joint OA impacts independently on symptoms and function [ 4- 9], that it also frequently occurs in the absence of tibiofemoral disease [ 4, 6, 10- 13], and that its aetiology and, therefore, risk profile and management, may differ [ 12, 14- 17].
Since ∆PCO2 is now widely recognized as a valuable marker to evaluate tissue perfusion in septic shock, a clinician should be aware that acute changes in pH or PaCO2 induced by hyperventilation could impact ∆PCO2 independently of changes in tissue perfusion.
An explanation for a switch in the enhanced-risk genotype is not readily apparent; however, PON1 is a complex gene involved in multiple physiological processes, including organophosphate metabolism but also lipid peroxidation and oxidative stress (Li et al. 2003), which may impact neurodevelopment independently (Eskenazi et al. 2010) and/or jointly with organophosphate exposure.
Likely contributing to this effect, the two KLFs independently impacted basal levels of the anti-apoptotic factors MCL1 and BCL-XL in drug-naive cells.
A similar association with reduced physical function and job impairment is observed in patients with osteoarthritis; 35 however, there is no evidence that existing osteoarthritis independently impacted JE or JSN progression or HAQ-DI scores in this database.
