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Aβ-induced miRNA regulation may involve alterations in cellular localization that will not only impact function but also turnover rate of miRNAs [52].
Lesser the score, rarer is the substitution and thus is more likely to impact function.
Enforced CDK6 expression in LT-HSCs shortens quiescence exit and confers competitive advantage without impacting function.
A/V and T/N substitutions are conservative and unlikely to impact function.
Another mechanism for variation that can impact function of aquaporins is single nucleotide polymorphisms (SNPs).
Any or all of these aspects in varying combinations can impact function.
NP has also been found to substantially impact function and well-being in this age group [ 9].
Individual miRNAs are highly represented in β-cells (31), impacting function and mass both positively and negatively.
Assessing these two groups will assist us in understanding how individual characteristics interact with contrasting societal opportunities to impact function.
I have written about people with sexual abuse histories, and the importance of a partner understanding how past sexual abuse may impact functioning in intimate relationships.
Based on our proposed model, processing speed worked, in part, through negative symptoms to impact functioning.
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