Sentence examples for impact the affinity of from inspiring English sources

In Noxa-deficient mice, these cells are allowed to survive and impact the affinity of T and B cell responses [ 14– 16, 34].

Further assessment of the effects of enhancer risk variants has shown that they can alter transcription-factor-binding sites (TFBSs) and impact the affinity of transcription factors for chromatin, and/or induce allele-specific effects on target gene expression [ 6, 27- 40].

Indeed, gel shift assay experiments show that the environment of the GCC box greatly impacts the affinity of ERF proteins to the conserved cis-element.

Given the previously demonstrated relationship between the surface charge density and solution substrate interfacial energy, these results indicate that the variation in interfacial energy observed here is due to the differences in protein surface charge density, which impacts the affinity of the substrates for the aqueous solution (i.e., the hydrophilicity).

Using a saturation binding protocol, we found that MTα suppressed the maximum binding without any greater impact on the affinity of the radioligand, indicating a non-competitive mode of inhibition.

In our study, when we analyzed whether the T cell cross-recognition has an impact on the affinity of the T cell response, we found that for the peptides analyzed (13BF and 16B) similar patterns of affinity curves were found.

Since deletion of the N-terminal MBD domain can have an impact on the affinity of Cu+-ATPases for Cu+ [ 43, 48], it is thus difficult to compare results obtained in this study to ours.

The structures of MFS transporters [4 29] show that substrates bind invariably in the V-shaped cleft between the N-terminal and C-terminal halves of the protein, so if this also applies to TetA(B), then the model suggests that none of the mutations would have had a significant direct impact upon the affinity of tetracycline binding.

Here we show that mutagenesis of human antibody framework 3 residue VH-71Arg to the corresponding murine donor antibody site alanine (VH-71Arg → Ala) dramatically increased the stability of the humanised scFv while only having a minor impact on the affinity of the molecule.

Despite it, both gefinitib and erlotinib cannot be used to treat all lung cancer patients harbouring EGFR mutations due to mutation site heterogeneity which negatively impacts on the affinity of EGFR inhibitors to the mutated EGFR and consequently of the efficacy of the treatment.

These differences would be expected to impact the affinity and specificity of ligand binding.