The family bikes around the city and cooks organic food by candlelight, and the no-impact regimen mutates from family issue to family adventure.
Other factors that impact medication regimen complexity such as instructions to take drugs separately or with food were not considered (Libby et al. 2013).
Importantly, as described above, we considered 'clinical effectiveness' as a proxy for the net impact of regimen efficacy, tolerance without major toxicity, adherence, and personal choice to remain on treatment.
Study design must address the patient population to be enrolled, the patients' severity of disease, and how standard therapies impact the regimen being examined.
Finally, the impact of regimen frequency and pill burden on adherence and virological outcomes in RCTs may not necessarily generalize to desimplification, in which patients may perceive that their regimen has been reduced in quality.
Animal models are commonly used to test the efficacy of impact loading regimens on bone strength.
The impact-loading regimen will be performed a minimum of 3 times per week for the duration of the trial, in combination with the resistance and aerobic exercise.
In the past, before the emergence of MDR organisms became a common problem, the clinical impact of regimens using low imipenem dosages was relatively minor.
The impact-loading regimen involves several activities which we have been previously used in a year-long training study in postmenopausal women [ 34].
To be conservative, we anticipate that our resistance and impact-loading regimen will result in a modest increase of ~1%, whereas the active control regimen should have a negligible attenuating effect on BMD loss.
In addition to the clinic training, participants will be encouraged to undertake twice weekly home-based training incorporating aerobic activity (e.g. walking, cycling) and a modified version of the impact-loading regimen (only including hopping, leaping and drop jumping) for the duration of the study.
