Manuscript flows among journals revealed a modular submission network, with high-impact journals preferentially attracting submissions.
The latter two alterations preferentially impact the enzymatic activity of key enzymes.
Elevated lead (Pb) exposures preferentially impact low socioeconomic status (SES) populations, the same groups thought to sustain the highest levels of environmental stress.
Taking advantage of brain slices, which have preserved cortical layers and pyramidal cell polarity, we find that alterations in EphB2 function preferentially impact dendritic protrusions of basal dendrites in layer 2/3 and 5 neurons.
Limited access to services in rural areas may preferentially impact the provision of quality emergency care.
A recent study shows that treatment with JQ1 results in preferential loss of Brd4 at super-enhancers and consequent transcription elongation defects that preferentially impacted genes with super-enhancers, including MYC [ 94].
To test whether expression of wild type EphB2 or EphB2DN preferentially impacts dendritic protrusions in apical or basal dendritic arbors, we examined the density of spines and filopodia in the dendrites of transfected cortical pyramidal neurons in brain slice culture.
The area of the brain preferentially impacted in Parkinson's disease (PD), the substantia nigra (SN), contains high levels of MAO-B positive astrocytes which are themselves somewhat protected against the effects of H2O2 due to the fact that they contain high levels of both GSH and glutathione peroxidase which act in concert to detoxify H2O2 within cells [11] [15].
The nature of the oxidative stress preferentially impacts different locations [ 55]; for example, EGF signaling induces Trx1 oxidation [ 51], while Trx2 is preferentially oxidized with TNF-α treatment [ 56].
Noise preferentially impacting smaller fold-changes, particularly if it is directionally unbiased, is less likely to mislead GSEA, which focuses on detecting gene sets that are over-represented at the extremes of the overall fold-change distribution in a dataset [ 28].
