Sentence examples for impact on tolerability from inspiring English sources

Luck et al also demonstrated the benefit of video information prior to colonoscopy [ 15] but Bytzer et al found that an information video shown to patients preparing for colonoscopy had no impact on tolerability or anxiety [ 16].

These drug interactions may lead to suboptimal levels of antiretroviral drug and emergence of resistance, or may lead to supraoptimal levels with a negative impact on tolerability and side effects.

As the addition of cisplatin did not appear to impact on tolerability, aflibercept 6 mg kg−1 in combination with docetaxel 75 mg m−2 and cisplatin 75 mg m−2 was selected as the RP2D for the triplet combination and aflibercept dose-escalation was halted, although no DLTs were observed after the amendment.

Our study clearly underlines that the administration schedule of one of the drugs of a combination can have a major impact on the tolerability of the combination.

We evaluated concomitant medication usage during the first 6 months of the prospective, observational, European Schizophrenia Outpatient Health Outcomes (SOHO) study, examining its frequency, variation according to type of antipsychotic drug used, and impact on treatment tolerability.

In terms of formulation, we observe that the method used to incorporate E6020 into AF03 affects its partition between the oil and water phases of the emulsion which in turn has a significant impact on the tolerability (IV pyrogenicity test in rabbits) of this novel adjuvant combination.

When ezetimibe is co-administered with a statin, complementary effects on the lipid profile have been demonstrated, without significant impact on the tolerability profile of either drug [ 16, 17].

The quantitative analysis results conducted in this case study illustrate the importance of evaluating the adverse impact on error-tolerability.

Moderators are characteristics of subjects before treatment that have an impact on efficacy or tolerability.

The ACTION study demonstrated significantly greater efficacy of 13.3 mg/24 h versus 4.6 mg/24 h rivastigmine patch on cognition, as measured by the change from baseline at Week 24 on the total SIB score, without a marked impact on safety and tolerability [ 8].

A retrospective safety analysis of 50 studies that evaluated telmisartan either as monotherapy or combined with HCTZ confirmed that the addition of HCTZ did not have a negative impact on the excellent tolerability profile of telmisartan, which is comparable with placebo [ 101].