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Inclusion of multiple dependent variables allows us to assess the broader impact on the intervention including both hard end points as well as patient reported outcomes.
This may have impact on the intervention, although it is expected that patients in the intervention group and the control group will be affected in the same way.
The changed arrangements for payment for management of CHD may impact on the intervention in the main trial but the current findings and awareness of the impact of background policy should assist in our interpretation of the findings.
As a subsequent step, we removed nonsignificant covariates from the model, and because there was no significant impact on the intervention effect and model fit was better for the full model, we chose to retain these additional effects.
The proportion of missing outcomes compared with observed event risk not enough to have a clinically relevant impact on the intervention effect estimate; missing data have been imputed using appropriate methods.
Subgroup analyses were carried out to explore the impact on the intervention effect of pre-specified baseline subgroup variables: HbA1c, age, gender, number of medications, self-reported adherence, and prior randomization to the electronic medication-monitoring device.
Similar(51)
Of note, 25% of abstracts reported no quantitative information on the impact of the intervention on the primary study endpoint.
The next stage of analysis will focus on describing the impact of the intervention on the primary and secondary outcomes.
A similar picture emerged on analyses of the impact of the intervention on severity of symptoms.
In addition, we did not examine the longer term impact of the intervention on mobility, or the impact of the intervention on secondary outcomes such as length of stay, function, discharge destination, readmission rate post discharge and quality of life.
Hence, we don't know impact of the intervention on adherence of MDR-TB treatment.
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have implications for the intervention
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impact on response
impact on non-intervention
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com