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A quantitative evaluation of the study was also conducted and outcome of the intervention in terms of impact on quit rates is reported elsewhere (7).
In GPs' views, NRT also provided smokers with a sense of hope, which was considered as possibly the sole reason why NRT had an impact on quit rates.
In contrast, for those individuals with a minor allele for rs2236196, the impact on quit rates was negligible (OR = 0.89; 95% CI 0.31 2.50).
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Although the weight of treatment in the total TCS score is limited (10 out of 100 points), the impact on quitting seems to be important at the ecological level.
Although, the hospital has not launched special campaigns addressed to them, we believe that the several cessation training programs addressed to nurses - who are 40% of our work force and from them 90% are women- may have had a stronger impact on quitting among this group.
However, the impact of quitting on individual diseases is not modelled.
The QBM only considers the impact of quitting on the smoker.
[ 3- 5] These analyses have found that interventions that encourage and facilitate quitting are very cost-effective, with net cost savings in some instances.[ 5] However the economic impact of quitting on macular degeneration has not been analysed.
So, in summary, the QBM under-estimates the benefits of quitting, as the model only considers the impact of quitting on a sub-set of the adverse health effects of smoking and the assumptions underpinning the parameter estimates were mostly conservative.
Sarna et al 12 evaluated the impact of quitting smoking on changes in HRQOL over an 8-year period among women in two cohorts.
Further research should examine whether the lack of impact of genetic attributions on quit attempt success is also found in smokers provided with personalized genetic feedback.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com