Sentence examples for impact on potency from inspiring English sources

Due to potential impact on potency and immunogenicity, it is important to understand the formation mechanism of such variants so that appropriate control strategies can be implemented to assure product quality.

In the course of these studies we noted differences in LF potency between sources and individual preparations which suggested that variability at the N-terminus of the protein might have an impact on potency.

However, the V138A3.36 mutation of TM3OX2 had no impact on potency (see Table 1).

Our results showed that modification on steroid core > modification on lactone ring > modification on sugar in decreasing impact on potency.

In the case of OX1, F5.42 interacts with H26 of OxA that, based on the SDM experiments, has an only moderate impact on potency (see Figure 6A).

The SAR profile (pattern of structural requirement for activity modulation) for antimigratory activity is: modification on steroid core > modification on lactone ring > modification on sugar in decreasing impact on potency.

The inhibition studies indicated that 5 is a potent VKOR inhibitor, which confirmed that the replacement of the tetrahydronaphthalene on diphenacoum to a chroman functionality does not have a major impact on inhibition potency.

The lower prevalence of khat use in PLHIV in our study compared to these previous Jimma population studies might be related to HIV status, for example, PLHIV being less likely to use khat because they felt ill or they thought that khat using may have a negative impact on the potency of the antiretroviral drugs.

For allele-selective inhibition of HTT expression, our mechanistic studies had suggested that binding of mismatch-containing duplex RNAs was cooperative and that cooperative binding of multiple duplexes weakened any detrimental impact of mismatches on potency.

These differences had a significant impact on the calculated potency of the commercial vaccines (Table  3) and demonstrate the need to have well-matched reagents for the pandemic H1 vaccine antigens in manufactured products.

We found that T-cell activation induced resistance to Bcl-2 inhibition by ABT-737 (no binding of A1 and Mcl-1) and by Antimycin A (no binding of A1 only), but had no impact on the pro-apoptotic potency of the pan-Bcl-2 inhibitor obatoclax.