Although relatively little or no research on the functional impact of apathy-emotional blunting has been conducted so far, some reports suggest that the emergence of this BAE could have a negative impact on normal functioning (Barnhart et al. 2004; Price et al. 2009; Padala et al. 2012; Rothschild et al. 2014).
Taken together, these findings suggest that experience with health problems – through ageing, chronic illness or a severe disorder – and better understanding of their impact on normal functioning at older age possibly influenced respondents' perception of what is acceptable.
Less-than-complete α-synuclein suppression, as achieved in our study, would be less likely to have a negative impact on the normal function of the protein.
Moreover, stress is known to have a detrimental impact on the normal function of the dopaminergic system [ 8].
The condition of neurovascular dysfunction disrupts the bioactivity and signaling of growth factors, such as vascular endothelial growth factor and brain-derived neurotrophic factor, which has an impact on the normal function and survival of the cells in the neurovascular unit.
Importantly, it was shown that the exogenous GFP expression in these cells did not affect their capacity to differentiate into end stage cell types such as chondrocytes, osteocytes, and adipocytes suggesting the appropriateness of the viral based gene delivery methods for therapeutic use due to their minimal impact on normal cellular function.
131I and 211At are taken up by the thyroid to a greater extent than in other tissues [16, 17], which can have an impact on normal thyroid function.
Perhaps the most pressing question relating to in vivo cell fusion is if the generated cell fusion hybrids have a physiologic impact on normal organ function.
The differential abundance of UMOD urine peptide biomarkers in SJIA suggests that SJIA is likely to have an impact on normal kidney function.
Understanding the dual nature of NMDA receptor function could allow for therapeutic targeting of specific prodeath signals, which if identified and successfully blocked might have a therapeutic effect with little impact on normal synaptic function.
