However, Üstün [ 11] argued that a clear differentiation between ADHD symptoms on the one hand, and their impact on functioning on the other, is crucial for a better understanding of how ADHD as a neurodevelopmental disorder can diversely influence individual functioning.
Caring for someone with a chronic condition can be a risk factor as it can impact on functioning or lead to an acceleration of decline in functionality (Vitaliano, Young, & Zhang, 2004).
Fourthly, one can debate whether all diseases have the same impact on functioning and result in the same burden.
Although the current prevalence observed here may appear not very high, up to 46% of the subjects presented at least one symptom with a clinical or subclinical significance and some impact on functioning in the ADHD screening, eventually qualifying for a diagnosis of ADHD-NOS.
It is the intensity of the anxiety experienced, the wider range of feared social situations, and the profound negative impact on functioning that sets SAD apart from milder instances of social apprehension.
Variables were grouped in this way due to the established impact on functioning, morbidity and mortality (WHO 2013).
Interviews captured information regarding the onset, duration, location, frequency, severity, bother and impact of symptoms and their associated impact on functioning and other key domains of health status.
The elevated odds ratios for a "severe impact" HIT-6 score (≥56) is consistent with the above findings for MIDAS and suggests a more general impact on functioning from MM than the work role.
In this case, a significant improvement in both primary (mean headache days) and secondary end points (mean drugs consumption and mean days with consumption) at 12 weeks, as well as in pain intensity and headache impact on functioning (HIT-6 and MIDAS) across all time points (4 and 12 weeks) was found.
No differences were detected at any time point between the onabotulinum toxin A- and placebo-treated subjects in primary and secondary end points, as well as in pain intensity and headache impact on functioning scores in subgroups of patients with cephalic allodynia (all p > 0.05).
Its impact on functioning and well-being has been compared to that of chronic medical conditions such as diabetes.
