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Genetic analyses that consider groups of rare variants will improve in power if functional variants can be separated from those that have no impact on function so that association tests and follow-up experiments can focus on the functional variants.
Approximately one quarter of respondents experienced tremor with at least some impact on function (mild or worse tremor).
Moreover, given that function is a more distal concept, and that the inclusion/exclusion criteria of the current trial were created to identify subjects with ADHD symptoms and not functional impairment, it is expected that there will be a lesser impact on function in this population.
Still, he said: "Having said that, it's hard to see its impact on function.
Impact on function was assessed in Xenopus laevis oocytes with electrophysiological experiments using the two-electrode voltage clamp method.
Segmental mandibular defects secondary to infectious, traumatic, and pathologic conditions can be debilitating because of their impact on function and facial esthetics.
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Fourthly, one can debate whether all diseases have the same impact on functioning and result in the same burden.
Previous studies have shown that proactive efforts to improve home care and function can have a positive impact on functioning and other health parameters.
Variables were grouped in this way due to the established impact on functioning, morbidity and mortality (WHO 2013).
Interviews captured information regarding the onset, duration, location, frequency, severity, bother and impact of symptoms and their associated impact on functioning and other key domains of health status.
Its impact on functioning and well-being has been compared to that of chronic medical conditions such as diabetes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com