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In mice receiving the gefitinib trastuzumab combination, reduction in tumour volume was inferior to that predicted by the observed impact of the agents alone.
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It is clear from this that, in considering the choice of an adhesion-reduction agent, the cost as well as the clinical impact of the agent needs to be considered carefully.
We also explore the biological basis of the good tolerability of gefitinib and discuss the impact of the agent's side-effect profile on its risk:benefit ratio.
In order to investigate the mechanism of action of APC in our experimental model, we studied the impact of the agent on ERK activation in lung tissue.
As the majority of the costs of managing diabetes are attributable to managing complications, this evidence would also be important in assessing the potential economic impact of the agent.
Further clinical studies are warranted to identify the impact of these agents on the treatment of cancer patients.
Therefore, a large-scaled randomized trial will be necessary to clearly define the impact of these agents on the endothelial function.
Therefore, the impact of these agents on co-occurring psychiatric symptoms has not been explored fully.
In addition, the impact of those agents on coagulation function in vivo, including thrombin generation, was examined.
However, the relative impact of these agents will often be largely determined by the nature and extent of human intervention.
Evidence also suggests that there is a 'fibrate effect' that mediates the reduction in CAD risk beyond the favorable impact of these agents on HDL-C levels.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com