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Importantly, as described above, we considered 'clinical effectiveness' as a proxy for the net impact of regimen efficacy, tolerance without major toxicity, adherence, and personal choice to remain on treatment.
Finally, the impact of regimen frequency and pill burden on adherence and virological outcomes in RCTs may not necessarily generalize to desimplification, in which patients may perceive that their regimen has been reduced in quality.
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In the past, before the emergence of MDR organisms became a common problem, the clinical impact of regimens using low imipenem dosages was relatively minor.
In contrast, a PK/PD model of HDL-C and ApoA-I data would enable the selection of dose regimen that achieves their target values, but would not be suitable for assessing the impact of dose regimen on quantities that have not been experimentally measured, such as pre- β1.
Daily subcutaneous self-injection of GH is used worldwide to treat short stature in childhood; longitudinal data on the impact of this regimen on GH-uptake are lacking.
The impact of this regimen on the incidence of nosocomial pneumonia is less clear [ 31, 32].
Secondary objective was to assess the impact of this regimen on overall survival and progression-free survival.
By using the current utility scores, models can quantify the impact of treatment regimen and adverse events when comparing the value of new and previously available treatments.
A study was conducted to assess the impact of feeding regimen on the recovery of labelled bicarbonate and energy expenditure in adult female pigs (sows).
The only impact of ART regimen was a smaller fall in markers of immune activation with ATV/r than with EFV.
We were unable to account for the impact of ART regimen changes (both inter- and intra-class drug changes) within our logistical regression model.
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