Exact(2)
Data were collected as part of a larger study of the use and impact of protocols in clinical settings [ 13, 14].
The obtained sequencing data were analyzed for: library complexity and reproducibility; rRNA removal efficiency and bias; the number of genes detected; coverage uniformity; and the impact of protocols on expression biases.
Similar(58)
We agree that there needs to be time for the existing efficiency measures – and the full impact of protocol 14 – to be properly evaluated.
The potential impact of protocol deviations is the dilution of the treatment effect [ 26, 27].
A sensitivity analysis will be performed on the primary variable to assess the impact of protocol deviations using the per protocol analysis set.
A sensitivity analysis will be performed on the primary efficacy endpoint to assess the impact of protocol deviations using the per protocol analysis set.
The primary analysis was by intention-to-treat; however, a per-protocol analysis was also planned to assess the impact of protocol violations, if any, on the primary endpoint.
In a group of subjects from Pisa, Italy not included in the original ESCH database cytogenetic slides could be retrieved from freezers, stained, and scored all together, minimizing the impact of protocol variation, reagents drift, and scorer heterogeneity.
Statistical analysis was performed on an intent-to-treat basis to minimize the impact of protocol violations (which may occur after randomization) on the results and conclusions and to avoid an overestimation of the treatment effect.
Therefore, we decided to conduct a random, parallel design so as to ensure internal validity (equivalence between groups, minimal likelihood of confounding); however, to the extent that our study suffered from a potential Hawthorne effect, this will most likely have resulted in an under-estimation of the impact of protocol-guided test ordering.
Moreover, an explicit expression of the consensus function which is independent of time delays is presented, and the impacts of protocol states and interaction topologies on the consensus function are revealed.
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